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Generally, hyperacetylation of histone is associated with transcriptional activation, whereas hypoacetylation is associated with transcriptional repression ( Figure 1 Histone/Lysine Acetyl Transferases (HATs or KATs) In humans, there are about 30 known HAT/KATs, which have been grouped into five distinct families based on the functional and structural similarity of their catalytic domains (Wapenaar and Dekker, 2016)

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Impaired Intestinal Permeability Contributes to Ongoing Bowel Symptoms in Patients With Inflammatory Bowel Disease and Mucosal Healing

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