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Acetyl-L-carnitine protects against LPS induced depression via PPAR- induced inhibition of NF-B/NLRP3 pathway More details Hide details 1 Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan 2 College of Natural and Health Sciences, Zayed University, Abu Dhabi, United Arab Emirates 3 Department of Pharmacology, Bannu Medical College, Bannu, KP, Pakistan 4 Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia 5 University of Lahore Islamabad Campus, Islamabad, Pakistan 6 State Key Laboratory of Oncogenomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen, China Submission date: 2021-08-15 Final revision date: 2021-12-08 Acceptance date: 2021-12-20 Online publication date: 2021-12-27 Corresponding author Fawad Ali Shah Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, Pakistan Introduction: Major depressive disorder (MDD) is a debilitating human health status characterized by mood swings and high suicidal attempts