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Research has also examined its role in upregulating matrix metalloproteinase (MMP) activity alongside their inhibitors (TIMPs), suggesting a finely balanced role in extracellular matrix remodelling rather than simple collagen deposition

After consideration of the comments we received, we are finalizing our proposal not to implement the PE/HR data or cost shares from the AMA's survey data at this time, and to maintain the current PE/HR data and cost shares for CY 2026 PFS ratesetting

& Fabbri, E

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