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Side Effects and Safety Considerations Both peptides share similar side effects due to melanocortin receptor activation, including: Nausea Vomiting Facial flushing Headaches Temporary increases in blood pressure Melanotan II poses additional risks such as: Darkening of existing moles Development of new moles Potential increased melanoma risk PT-141 is legally available only via prescription in some regions due to cardiovascular and blood pressure considerations

Cognitive techniques from CBT can help to identify and challenge general and diabetes-specific cognitive distortions resulting in maladaptive behavior and are usually complemented with behavioral techniques, including behavioral activation and specific behavioral change strategies related to diabetes and mood [218]