[14] That the same study raised both a matrix-degrading enzyme and its inhibitors is itself telling: it suggests a coordinated remodeling program rather than a simple push in one direction, which is consistent with the idea of GHK-Cu as an organizer of repair
These materials demonstrate high pH sensitivity, where acidic conditions trigger a surge in fluoride release, particularly pronounced in systems containing CaF 2 or fluorohydroxyapatite under cariogenic pH (4.5-5.5) generated by bacterial metabolism (Morawska-Wilk et al., 2025)
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