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The MTC association was identified in rodent studies at doses substantially higher than those used clinically

Using CRISPR-Cas9 in human and mouse cells, genome-wide, targeted loss-of-function pooled screens have been studied that has provided information about the inactivated genomic loci and strategies that modulate transcriptional activities (Sanjana et al., 2014)

RNA-seq and subsequent gene set enrichment analysis (GSEA) revealed that the liver tissue from Gclc KO mice was enriched in several gene signatures associated with stress responses, including those related to the activation of NRF2 (Fig