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Those following vegan or vegetarian diets (limited dietary B12 intake)

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The compound appears to work by increasing intracellular NAD+ levels (through preventing nicotinamide consumption by NNMT), which activates sirtuins and enhances mitochondrial function and fatty acid oxidation, while also promoting a phenomenon called "browning" of white adipose tissue - the transformation of energy-storing white fat cells into metabolically active beige/brown adipocytes that burn fatty acids for thermogenesis rather than storing them

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A shift from pink to clear in a B12-containing formulation suggests B12 degradation, most commonly caused by light exposure