glp 1 positive effects Frontiers IUPHAR review – Glucagon-like peptide-1

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Nishimura and colleagues showed that loss of ATM in melanoblast stem cells within the hair follicle bulge region in mice could sensitize the stem cells to genotoxic stress, leading to early differentiation, depletion from the niche and progressive hair greying over subsequent cell cycles due to eventual depletion of mature melanocytes from the hair bulb 3,10

A composite analysis of 8 cardiovascular outcomes trials completed in 2021 demonstrated reduced incidence of major cardiovascular events by 14% and cardiovascular death by 13% (NCT01147250, NCT01179048, NCT01720446, NCT01144338, NCT02465515, NCT01394952, NCT02692716, NCT03496298)

GLP-1 powders and, in general, powder supplements allow for higher ingredient dosages that may not fit into capsules or gummies, which improves the overall effectiveness

Its rare to have a company study the full formulation rather than focus on one or two ingredients. The short of it