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reported that ZIKV induces ROS production and suppresses the activities of antioxidant enzymes, including SOD and catalase, in U87-MG (human glioblastoma) and HepG2 (human liver carcinoma) cell lines 50

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Furthermore, icv infusion of GLP-1 in fasted rodents increases the synthesis of anorexigenic peptides (POMC and cocaine- and amphetamine-regulated transcript (CART)) both in arcuate and paraventricular nuclei [94]

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The 6J substrain has a deficiency of the mitochondrial enzyme nicotinamide nucleotide transhydrogenase (NNT), which transfers electron from NADH to NADP + thereby supporting the antioxidant glutathione peroxidase in mitochondria