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[1] [2] [3] [20] In order to prevent mitochondrial malfunction and sustain metabolic function/energy generation (ATP), NAD+ supplementation may counterbalance the age-related degradation of NAD+ and its precursor nicotinamide mononucleotide by NADases, particularly CD38

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For example, oral administration of fiber or SCFAs in mice shifted peripheral clock gene phases in a time-dependent way, implying that dietary fibers could be used to correct circadian misalignment via the microbiome