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[DOI] [PubMed] [Google Scholar] 76.Pramod A

Any psoriasis improvement with GLP-1 therapy likely occurs indirectly through substantial weight loss, which reduces systemic inflammation and pro-inflammatory adipokines

Doing so floods your system with semaglutide and overwhelms your GLP-1 receptors, leading to severe gastrointestinal side effects and inconsistent dosing patterns that undermine your weight loss protocol

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After a month-long break, a conservative approach often involves restarting at a lower dosetypically the starting dose of 2.5 mg weekly or one step below the previous maintenance dosethen re-escalating according to the standard titration schedule