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Oral administration of cysteamine, although efficacious for cystine depletion in nephropathic cystinosis, is associated with poor patient compliance due to the unpalatable taste, odor of sulfur, and gastrointestinal side-effects such as nausea, vomiting and pain, coupled with a requirement for frequent, high dosing to overcome extensive first pass metabolism of the cysteamine
Nassir F, Ibdah JA (2014) Role of mitochondria in nonalcoholic fatty liver disease
Its functional benefits include improved fat utilization, reduced lactate accumulation, enhanced endurance, delayed fatigue onset, and increased exercise efficiency (Simmons et al
According to Dluzniewska et al., MGF is naturally produced in the brain after hypoxic injury and is over-expressed in the segments with the greatest neuronal damage
[DOI] [PMC free article] [PubMed] [Google Scholar] 77.Ginsberg Y., Khatib N., Weiner Z., Beloosesky R
