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Disruption of the gut microbiota early in life, for instance via antibiotic exposure, can result in long-lasting changes to visceral pain sensitivity and stress responsiveness, as demonstrated in rodent models (O'Mahony et al., 2014

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However, in some cases, it may cause certain mild side effects to people with highly sensitive skin

doi: 10.1016/j.bioorg.2006.09.003

The liver detoxifies xenobiotics and endogenous waste products through conjugation reactions, but fat metabolism (lipolysis and beta-oxidation) is regulated by insulin, glucagon, epinephrine, and adipose tissue lipase activity