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"Lean mass changes during GLP-1 receptor agonist therapy: mechanisms and mitigation strategies." Molecular Metabolism

The math behind accumulation For the mathematically curious, here is what the plotter calculates

In particular, since CB1Rs, the main target for the rewarding effects of cannabis, are expressed on incretin-secreting cells in rodents and may play a role in regulating GLP-1 secretion [58, 59]

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GLP-1 receptor agonists have revolutionized weight management, but discontinuing them requires careful planning to maintain results and avoid rebound weight gain