Meanwhile, dual agonists, which target and activate both the GLP-1 (Glucagon-like peptide-1) receptor and the GIP (glucose-dependent insulinotropic polypeptide) receptor, and triple agonists (targeting the GLP-1+GIP+Glucagon receptors) are also showing promise
Conclusion: We successfully developed biomimetic lysosomal-targeted PD-L1 degradation peptides that induced M1 polarization of TAMs, increased HCC immune cell infiltration, reversed HCC immune tolerance, and significantly activated anti-cancer responses
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