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Innovations introduced longer-acting formulations: semaglutide (novel peptide with fatty acid modifications) enabled once-weekly dosing and was first approved as Ozempic (T2D, 2017) and then as Wegovy (obesity, 2021)

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For example, recent mechanistic studies show that quercetin can ameliorate obesity and inflammation by modulating the gut microbiota to promote the production of metabolites like indole-3-propionic acid (IPA), which in turn enhances intestinal barrier integrity and suppresses chronic inflammation (29) (Figure 1)

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