GLP-1 agonists are being used in combination with basal insulin (Dungan & DeSantis, 2016), although this is not an FDA-approved indication (see rxlist.com) they should not be used as a substitute for basal insulin, as this has been found to result in a decline in glycemic control)(Dungan & DeSantis, 2016) Clinical trials indicate it can reduce HbA1c by ~0.8% Undergoes renal clearance, with dosage reduction needed if creatinine clearance falls to 1.5
Hydration, gradual fiber intake, movement, and consistency are key strategies for regular bowel movements while taking GLP-1 medications
What counts is how well it holds a safe, steady temperature for hours
Many users report that gastrointestinal side effects are most pronounced when starting and tend to diminish over time
Protective effect of exendin-4 treatment on erectile dysfunction induced by chronic methylglyoxal administration in rats