glp-1-based therapy Can GLP-1 Medications Affect Athletic Performance and Recovery? GLP-1 Essentials - TRC Healthcare

Tirzepatide (Zepbound, Mounjaro) Tirzepatide is a first-in-class dual agonist

Leptin receptor expression in nodose ganglion cells projecting to the rat gastric fundus

Generally, GLP-1 medications are considered for adults whose body mass index and medical history meet established clinical criteria

Additionally, the serine protease dipeptidyl peptidase 4 (DPP4) limits the bioavailability of GIP, GLP-1, and GLP-2 by cleaving the first two amino acids, rendering them inactive (Deacon et al., 1995a

This combination creates a double risk for B12 deficiency, as both medications can impair absorption through different mechanisms