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10.1016/j.phrs.2020.104784 Pharmacol Res

doi: 10.2337/dc17-0417 [DOI] [PubMed] [Google Scholar] 32.Buckley ST, Bkdal TA, Vegge A, et al

They are contraindicated for individuals with medullary thyroid carcinoma or Multiple Endocrine Neoplasia type 2

For example, the SELECT trial reported that semaglutide reduced the risk of MACE by 20% (Hazard Ratio (HR) 0.80, 95% confidence interval (CI) 0.720.90) in people with obesity but without diabetes, although several secondary outcomes did not reach statistical significance under hierarchical testing procedures

In some cases, particularly with very significant weight loss, skin may not fully retract