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PT-141 is a synthetic cyclic melanocortin peptide

( Glutathione: a key player in autoimmunity, Carlo Perricone, Caterina De Carolis, Roberto Perricone, Autoimmunity Reviews, 2009, doi: 10.1016/j.autrev.2009.02.020., ( Effect of Glutathione Infusion on Leg Arterial Circulation, Cutaneous Microcirculation, and Pain-Free Walking Distance in Patients With Peripheral Obstructive Arterial Disease: A Randomized, Double-Blind, Placebo-Controlled Trial, Enrico Arosio, MD, Sergio De Marchi, MD Massimo Zannoni, MD, Manlio Prior, MD, Alessandro Lechi, MD, Mayo Clinic Proceedings, DOI: (

C600031-0010) at 4 C for 30 min and then collected by low-speed centrifugation

As discussed in the CY 2025 PFS final rule, we also learned that increases in the performance threshold add administrative and financial burden for small practices that discourage their participation in MIPS (89 FR 98451 through 98454)