why do glp 1 cause fatigue GLP-1 Fatigue: It Happens And What To Q&A: Why Do I Feel

When ODonnell-Giles worked with an Ironman triathlete on a GLP-1, we had to nail her protein to prevent injury and promote recovery

Additionally, environmental factors such as iodine excess or deficiency, smoking, stress, exposure to chemicals, medications (e.g., amiodarone, interferon-), and some viral/bacterial infections can alter gene expression patterns through epigenetic mechanisms and trigger autoimmune processes

Last reviewed: June 4, 2026 Last updated: June 4, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Increases typically happen every four weeks

These medications influence appetite regulation, slow stomach emptying, and improve blood sugar control by acting on several metabolic pathways at once