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ER stress triggers three branch pathways of the UPR, involving activation of transcription factor 6 (ATF6) (Shen et al., 2005), IRE1 (Chen and Brandizzi, 2013), and PERK (Figure 1)

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[14] Review literature reports that endogenous plasma GHK falls from roughly 200 ng/mL around age 20 to under 80 ng/mL by age 60