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In the Trx system, NADPH acts as the primary electron donor, transferring electrons to Trx-S2 via TrxR, thereby driving its reduction to the active form [Trx-(SH)2] (36)

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Y.KimK.et al

Significantly, VX765 exerts a distinctive synergistic effect by suppressing inflammasomeassociated caspase1 activity, which averts proinflammatory signalinduced destabilization of SAMHD1