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BMJ Open Gastroenterology

Lobkovich A, Kale-Pradhan P, Lipari M

The transcription factor p53 also plays a dual role in melanocyte defense by upregulating tyrosinase, a key enzyme in melanogenesis, and enhancing the antioxidant response via the Nrf2 pathway 17 , but also it can stop the melanocyte cell cycle, even leading to apoptosis 79

In summary, this review has identified several natural productssuch as Withania somnifera , Ocimum sanctum , curcumin, and Astragalus membranaceus that have demonstrated significant effects on thyroid function or pathology in preclinical models, with some like Astragalus and Dioscorea nipponica showing promise in preliminary clinical studies