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Notably, 48% of participants planned to take GLP-1RA indefinitely

While no studies have indicated a beneficial effect of liraglutide or semaglutide in Parkinson's Disease, a study with exenatide has indicated that long-acting GLP-1RAs may prevent deterioration in motor symptoms in patients with the condition (209), and the suggested mechanism may be a microglia-initiated effect to prevent astrocytes from forming a toxic phenotype (121, 210)

Baseline metabolic factors, insulin resistance severity, concurrent medications, and genetic variation in lipid metabolism genes influence the magnitude and timeline of triglyceride improvement

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