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There is also an ongoing cardiovascular outcomes trial of tirzepatide (SURPASS-CVOT) in individuals with type 2 diabetes and cardiovascular disease [91], which, if successful, will broaden the use of tirzepatide to those with manifest or increased risk for CVD, as is the case for GLP-1 receptor agonists [22]

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Previous medications offered modest 5-10% weight loss at best

Why it Works Stronger appetite suppression Targets hunger & insulin response Dual-pathway targeting for deeper appetite control Best for Breaking through weight loss plateaus Need stronger appetite control GLP-1 Microdose Plan GLP-1 receptor agonist micro-titration Same medication half the dose, twice a week Step up to a full plan anytime youre ready Start low, go slow

Molecular Pharmaceutics, 14 (9), 2861-2863