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For high-fat diet experiments, mice were fed a 60 kcal% fat high-fat diet (Research Diets, D12451i) following either tamoxifen or AAV-TBG-Cre injection for 2-3 weeks

In addition, the available evidence suggests an effect in reducing the incidence and severity of AMS in humans ( 2 Methodology 2.1 Study design The research design followed the PRISMA 2020 protocol for systematic reviews and meta-analyses, aiming to identify studies evaluating the effect of antioxidant therapies on Acute Mountain Sickness, a condition resulting from high-altitude exposure (Figure 1)

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Weiss EP, Villareal DT, Fontana L, Han DH, Holloszy JO