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placebo of +9.3 (95% confidence interval [CI] +6.5, +12.1) vs

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1,3 It is important to note that BD is a heterogeneous disorder, and metabolic dysfunction - including IR - likely represents one of several interacting pathophysiological pathways rather than a universal mechanism in all patients

Unlike older medications such as phentermine or orlistatwhich suppress appetite via the central nervous system or block dietary fat absorptionsemaglutide enhances feelings of fullness and reduces hunger, helping our patients decrease their calorie intake more effectively