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In animal stroke models, GLP-1RAs have been associated with various beneficial direct cerebral effects, such as reduced infarct volume, apoptosis, oxidative stress, mitochondrial dysfunction, neuroinflammation, excitotoxicity and BBB permeability, and increased neurogenesis, neuroplasticity, angiogenesis and CBF
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Some individuals tolerate popcorn well, while others find that its high fiber content and indigestible hulls (the hard outer shells) cause discomfort, particularly if they are already prone to bloating, gas, or constipation on the medication
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This is why GLP-1 drug makers acknowledge these may need to be taken indefinitely
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