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The limited efficacy of current antidepressant therapies can be explained by the heterogeneity of depressive disorders

Many patients discontinue GLP-1 medications due to cost or side effects like nausea and fatigue

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In the SUSTAIN 6 cardiovascular outcomes trial (published in NEJM 2016), semaglutide reduced the risk of major adverse cardiovascular events (MACE) by 26% compared to placebo in patients with type 2 diabetes and established cardiovascular disease or multiple cardiovascular risk factors