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Indeed, if we replace the models of two c-METs from our structure of c-MET/HGF holo-complex to the N-terminus disordered c-MET, the distance between the two IPT2 domains is increased from 20 to 44 , suggesting that the compact c-MET is not in an ideal conformation for activation, which supports our hypothesis

As mandated by law, these research chemicals are exempt from regulation under Title 21 of the Code of Federal Regulations and are strictly for laboratory use

This condition arises when the skins pigment-producing cellsmelanocytesbegin to produce excess melanin, which causes uneven skin tone

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