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In addition to energy production, mitochondria perform other cellular functions: Transport and storage of calcium ions used for cellular processes like muscle contraction and signal transduction Release of certain proteins to initiate programmed cell death Regulation of cell differentiation and growth Synthesis of heme, a molecule needed for hemoglobin production hemoglobin carries the oxygen transported by red blood cells Glutathione supports mitochondrial health by neutralizing harmful reactive oxygen species (ROS) that are byproducts of energy metabolism

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A typical example is to develop an MnO 2 -based nanocarrier for chemotherapeutics delivery, which could degrade and release drugs in response to overexpressed GSH (Lin et al., 2018)