Direct and Metabolite Effects: While direct GLP-1R expression on -cells is low, degradation products of GLP-1, such as GLP-1(9-36) , may also inhibit glucagon secretion by activating inhibitory G proteins (Gi/o) and modulating calcium channels (Zheng et al., 2024)
Because if you stop the therapy, what happens is that you regain weight, most likely, and that will be fat and not lean body mass
This would have never happened without them, man
Similarly, individuals with pre-existing gastrointestinal conditions such as irritable bowel syndrome may experience exacerbated symptoms with allulose consumption due to its osmotic effects
doi: 10.1056/NEJMra1615439 Summary Keywords diabetic peripheral neuropathy, glucagon-like peptide-1 receptor agonists, neuroprotection, inflammation, oxidative stress Citation Liu C, Wu T and Ren N (2024) Glucagon-like peptide-1 receptor agonists for the management of diabetic peripheral neuropathy