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10.1016/j.cell.2021.01.020 168 WuM.HanW.SongS.DuY.LiuC.ChenN.et al (2018)

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3,4 Further cytokine production can occur as the LL37/DNA complex can act as an auto-antigen by fitting into the groove of human leukocyte antigen-Cw6 that is then presented to the T-lymphocyte

However, a pharmaceutical patents protection extends far beyond the core active ingredient, or composition of matter. A robust patent portfolio, often referred to as a patent thicket, can also cover the drug products specific formulation, a new method of using the drug, or even a novel combination with another active ingredient