retatrutide liver Triple hormone receptor agonist for metabolic dysfunction-associated steatotic disease: a randomized phase 2a trial Retatrutide 12 mg resolved steatosis

(2) Saponins: Astragaloside IV, an active component of Astragalus, activates the PI3K/AKT and Nrf2 signaling pathways, reduces oxidative stress, enhances GPX4 and Nrf2 expression, reduces iron accumulation, inhibits ferroptosis induced by Aflatoxin, significantly improves kidney damage, and protects kidney cells (178)

However, the key limitations of existing studies lie in small clinical sample sizes without multicenter validation and unstandardized intervention protocols in animal models, both of which impede clinical translation

GCLC knockout mice die within a month of birth due to the absence of hepatic GSH synthesis

Increased neonatal fat mass, not lean body mass, is associated with maternal obesity

(5) All sources used are properly disclosed (correct citation)