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Paragraph IV filing data, publicly available through the FDA Orange Book, gives PBM formulary teams early intelligence on generic entry timelines that manufacturers should be actively monitoring

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Receptor endocytosis, an intermediate step toward downregulation, is also necessary for resensitization via dephosphorylation and recycling 11, thus, totally inhibiting endocytosis will likely result in reduced signaling as surface receptors become desensitized via -arrestin recruitment

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