GHK-Cu is the more scientifically impressive molecule -- a naturally occurring tripeptide that modulates thousands of genes, outperforms Matrixyl in head-to-head wrinkle studies, and offers additional benefits for wound healing and inflammation
DSIP contains a tryptophan residue that makes it more light-sensitive, so extra attention to UV protection is warranted
Importantly, the application of ferrostatin-1 successfully mitigated the ferroptosis and EMT-related dysfunctions, indicating promising pathways for therapeutic intervention ( Tumor protein p53 (TP53) , Enhancer of Zeste Homolog 2 (EZH2 ), Tissue inhibitor matrix metalloproteinase 1 (TIMP1) , Solute carrier family 3 member 2 (SLC3A2), and Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) (Zeng et al., 2025)
Although oral GSH supplementation has poor bioavailability [4], N-Acetyl Cysteine (NAC) has been shown to successfully raise plasma glutathione levels in those with schizophrenia [5]
Yes, glutathione treatment is suitable for all skin types