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This was achieved by inhibiting bone resorption through an increase in the OPG/RANKL ratio and promoting bone formation by enhancing the expression of osteoblast-specific transcription factors.374 Exendin-4 has also been shown to stimulate osteoblast activity and mitigate bone loss in an ovariectomized mouse model.374 Liraglutide can directly enhance bone formation in the MC3T3-E1 osteoblastic cell line
The side effects were most commonly gastrointestinal disturbances such as nausea and vomiting and occurred in a similar frequency to those reported with dual receptor co-agonists [61]
The influence of Fab 3F52 on a short GLP-1 analogue BMS21 as well as on the ago-allosteric small-molecule compound 2 was evaluated 18,32
Furthermore, in obese individuals with sleep disorders, the secretion and activity of GLP-1 RA are decreased, which can lead to abnormal sugar metabolism and weight gain, thereby exacerbating OSA [63, 77, 78]
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