It identified adults aged 55 years or older, without diabetes, with overweight or obese between January 2004 and July 2025
On the other hand, the SURPASS-5 study showed tirzepatide at doses up to 15 mg weekly reduced HbA1c by up to 2.34% and produced weight loss of up to 10.5 kg over 40 weeks, outperforming placebo by a wide margin (NCBI Bookshelf)
Small, steady changes build lasting results far more effectively than extreme restrictions
moreover, significant weight loss reduces the requirement for procedures, such as coronary artery bypass grafting, carotid endarterectomy, and percutaneous coronary intervention, as well as peripheral vascular disease, and total mortality by up to 24% [89, 90]
Improved hormonal signaling also benefits other systems, like thyroid and reproductive health