PKC agonism restricts innate immune suppression, promotes antigen cross-presentation and synergizes with agonistic CD40 antibody therapy to activate CD8(+) T cells in breast cancer
Further, once patients achieve their desired weight, therapies that are safer, cheaper, and/or more convenient to administer may be needed to help sustain the durability of the response
Notes: Due to concern with Torsades de pointes (heart rhythm disturbance), cardiac arrest, and death, do not use higher than recommended doses of loperamide and avoid it in children under age 2
In most of the body, the enzyme that carries out this reaction is glutathione peroxidase
Over 68 weeks, Wegovy users exhibited significantly greater weight loss, attributed to reduced cravings and hunger leading to decreased food intake [5]