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SIRT1 is linked to circadian rhythms and cellular mechanisms, such as cell repair, division, metabolism, and growth (20)

When the annulus develops tears or weakens, the nucleus can bulge or herniate outward

By binding to receptors in both the pituitary and hypothalamus, it triggers robust, pulsatile GH release that mimics natural secretion patterns [2]

Lovera, J., et al., Lipoic acid in multiple sclerosis: a pilot study

Ten trials 13,14,2632 had sufficient data for the meta-analysis (n=366 treatment, n=359 control), and five trials 15,26,3335 were excluded from quantitative synthesis due to incomplete or non-extractable data