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hypothesized the central role of acrolein in the disruption of the structure of cell membranes in RBCs (changes in the cell membrane, cytosolic proteins, and osmotic sensitivity)

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The two human 3-hydroxysteroid dehydrogenases have been investigated in detail by Thomas and coworkers (e.g., + as a coenzyme remains as an intermediate bound to the enzyme prior to its isomerization to 4-AD