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Apart from regulating the free plasma IGF fraction, IGFBPs also play an important role in the transport of IGF into different tissues and extravascular space

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Dysbiosis of the hindgut microbiota, characterized by the depletion of acetate-producing genera (e.g., Faecousia ) and the expansion of acetate-consuming methanogens (e.g., Methanosphaera ), leads to a deficiency in intestinal acetate