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As an orphan receptor, no endogenous ligand has been identified for NHR-49

Semaglutide is a medication used for the treatment of type 2 diabetes and as an anti-obesity medication for long-term weight management

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[15] In both trials, after 72 weeks of treatment, participants who received tirzepatide at all three dose levels experienced a statistically significant reduction in body weight compared to those who received placebo, and greater proportions of participants who received tirzepatide achieved at least 5% weight reduction compared to placebo