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By acting on both the GLP-1 and GIP receptors, tirzepatide reduces appetite, increases feelings of fullness, and helps patients consume fewer calories

Studies in healthy adults, including periods of supplementation lasting several years, show no adverse effects on kidney function

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Chronic neuroinflammationmediated by activated microglia and astrocytesexacerbates neuronal injury through the release of pro-inflammatory cytokines such as TNF- and IL-1 (Singh et al., 2019)

At the same time, brain tissue is rich in unsaturated fatty acids and transition metal ions but has relatively fewer antioxidants compared to other organs, creating favorable conditions for oxidative damage