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2,3 The REDEFINE 1 trial found that when evaluating the treatment effect regardless of whether patients stayed on treatment, those treated with CagriSema achieved weight loss of 20.4% (from an average baseline body weight of 236 lb.) at 68 weeks versus 3.0% (from an average baseline body weight of 235 lb.) for the placebo group which was statistically significant

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It is a baseline equivalence check, generally utilized for moderate risk Class II devices, and requires zero trials proving efficacy

Safety for Daily Use of L-Carnitine A key question is: Is it safe to use L-Carnitine daily