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The most striking recent piece of evidence came from a 2026 study published in Cell Metabolism [12], which found that semaglutide appeared to reverse cartilage damage in a mouse model of osteoarthritis, and crucially, this effect was independent of weight loss

128,129 In one randomized controlled trial in 45 participants, 6 mg melatonin daily one hour before bed for 12 weeks was more effective than placebo at decreasing NAFLD severity, body weight and waist circumference, and liver enzyme levels, and improving inflammatory and metabolic markers

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Although all GLP-1R agonists are effective in stabilizing blood glucose levels, glycated hemoglobin (HbA1c), cholesterol levels, insulin sensitivity, and several other beneficial aspects of metabolism in T2D patients (Patel et al., 2014

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