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Media reports describe women with stomach paralysis, with severe effects continuing at least a year after discontinuing in two of three cases

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However, these cardiovascular applications require particularly careful consideration given the potential risks associated with promoting angiogenesis in patients who may have undiagnosed malignancies or other conditions where angiogenesis promotion could be detrimental

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Before considering any off-label combination approach, a comprehensive evaluation including genetic predisposition screening and biomarker assessment can help providers and patients optimize single-agent therapy