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Moreover, intersections between upregulated DEGs in the control group and downregulated DEGs in the treatment groups, as well as between downregulated DEGs in the control group and upregulated DEGs in the treatment groups, also demonstrated that the combination group had a greater overlap with the control group than either single-drug group did (Additional file 2: Figure S5)

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Research conducted by Cun Wangs team demonstrated the effective utilization of the senogenic compound (also known as a senescence inducer) XL413 and the senolytic compound AZD8055 in liver cancer therapy [136]

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