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Strong acids (AHA/BHA at high concentrations) and high-concentration vitamin C can destabilize the copper chelate separate application sessions or alternating days avoid the interaction

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The mechanism is aggregation: shear forces cause hydrophobic amino acid residues normally buried inside the peptide structure to flip outward, where they bind to hydrophobic regions on adjacent peptide molecules

Table 1 Kinetic parameters in the reduced model

Medication should not be the first course of action, and current evidence does not support its effectiveness as a sole form of treatment, nor do medical guidelines recommend such use